Improving brain and heart recovery after cardiac arrest by managing oxygen levels
Resuscitating the Brain and Heart Following Cardiac Arrest: Targeting Oxygen Toxicity
This study is looking at whether giving less oxygen right after a cardiac arrest can help patients recover better, and it's for anyone who has experienced this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11064863 on NIH RePORTER |
What this research studies
This research investigates how adjusting oxygen levels can improve recovery for patients who have experienced cardiac arrest. It challenges the common practice of providing high levels of oxygen after resuscitation, which may actually harm recovery. The study will test a new approach called oxygen restriction therapy (O2RT), where oxygen availability is limited for a short period after cardiac arrest. By observing the effects of this therapy on heart and brain function, the research aims to identify better treatment strategies for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a cardiac arrest and require mechanical ventilation.
Not a fit: Patients who are not mechanically ventilated or who have not experienced a cardiac arrest may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and neurological outcomes for patients recovering from cardiac arrest.
How similar studies have performed: While the approach of oxygen restriction therapy is novel, previous research has indicated that managing oxygen levels can significantly impact recovery outcomes in critically ill patients.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Sharp, Willard William — University of Chicago
- Study coordinator: Sharp, Willard William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.