Improving brain activity imaging techniques for better understanding of complex functions.
Optimization, Application, and Dissemination of Imaging Modules for High-speed Mesoscopic Volumetric Recording of Neuroactivity in Scattering Brains
This study is exploring new ways to see how the brain works by using special imaging technology to watch the activity of many brain cells at once in awake mice, helping us learn more about how our brains respond to different experiences and feelings.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10896325 on NIH RePORTER |
What this research studies
This research focuses on developing advanced imaging technologies to record brain activity in real-time and at high resolution. By utilizing a novel approach called Light Beads Microscopy, the team aims to capture the activity of up to 1 million neurons simultaneously in awake and behaving mice. This method combines two-photon microscopy with genetically-encoded calcium indicators to provide insights into how sensory inputs and internal states influence brain function. The goal is to enhance our understanding of brain-wide neuronal populations and their roles in complex behaviors.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would include individuals with neurological disorders or cognitive impairments that affect brain function.
Not a fit: Patients with conditions unrelated to brain function or those not experiencing cognitive or neurological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain functions and disorders, potentially informing new treatments for neurological conditions.
How similar studies have performed: Other research has shown success with similar imaging techniques, indicating a promising avenue for advancing our understanding of brain activity.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Vaziri, Alipasha — Rockefeller University
- Study coordinator: Vaziri, Alipasha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.