Improving bone health and healing in aging Veterans
BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Combined long-acting PTH and calcimimetics actions on skeletal anabolism
This study is looking at new ways to help older Veterans strengthen their bones and heal better after fractures by using a hormone called parathyroid hormone (PTH) to boost bone growth and repair.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10948075 on NIH RePORTER |
What this research studies
This research focuses on developing new methods to prevent osteoporosis and enhance bone regeneration in aging Veterans, particularly after fractures. A team of VA investigators will collaborate to explore how parathyroid hormone (PTH) can be used more effectively to promote bone formation and repair. By using pre-clinical models, they aim to identify innovative therapeutic strategies that can improve bone health and reduce the risk of fragility fractures. The study seeks to address the challenges of current treatments and find safer alternatives for managing bone health in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are aging Veterans who are at risk for osteoporosis or have experienced bone fractures.
Not a fit: Patients who are not Veterans or those without bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved bone health and faster recovery from fractures for aging Veterans.
How similar studies have performed: Previous research has shown promise in using PTH for bone health, but this approach aims to innovate and refine existing methods specifically for Veterans.
Where this research is happening
San Francisco, United States
- Veterans Affairs Med Ctr San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Chang, Wenhan — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Chang, Wenhan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.