Improving bone health and healing in aging Veterans
Official title: BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB): Zfp384-mediated enhancement of anabolic action in the skeleton
Funded at Rlr VA Medical Center · NIH-10904667 · Data updated 2026-11-12
This study is looking at new ways to help aging Veterans strengthen their bones and recover better after fractures, using a hormone called parathyroid hormone to boost bone growth and prevent osteoporosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rlr VA Medical Center NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | July 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| NIH project number | 5I01BX005861-03 |
| Project ID | NIH-10904667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging Veterans who are at risk for osteoporosis or have experienced bone fractures.
✕Less likely to help
Patients who are not Veterans or those without risk factors for osteoporosis may not benefit from this research.
What this research studies
This research focuses on developing new methods to prevent osteoporosis and enhance bone regeneration in aging Veterans, particularly after fractures. By utilizing pre-clinical models, the study aims to explore how parathyroid hormone (PTH) can be used more effectively to promote bone formation. The collaborative effort involves various VA investigators who bring different insights and techniques to tackle the significant issue of bone fractures, which can lead to serious health complications. The goal is to find innovative therapeutic strategies that improve bone health and reduce the risk of fragility fractures.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for osteoporosis and improved recovery from bone fractures in Veterans.
How similar studies have gone: Previous research has shown promise in enhancing bone health through innovative treatments, making this approach a continuation of successful strategies.
Where this research is happening
-
Rlr VA Medical Center
Indianapolis, United States Active
Researchers
- Principal investigator: Robling, Alexander G — Rlr VA Medical Center
- Study coordinator: Robling, Alexander G
Related research
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Intermittent Fasting to Boost Fracture Healing in Obesity and Type 2 Diabetes
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-
Next-Generation MRI to Predict Bone Healing Using Virtual Testing
A new MRI-based method uses advanced imaging and computer models to predict how well broken bones are healing, starting with shinbone (tibial) fractures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.