Improving bone health and healing after spinal cord injury
Official title: The Blockade of Siglec-15 as a Novel Approach to Improve Skeletal Integrity and Fracture Healing in Chronic SCI
Funded at James J Peters VA Medical Center · NIH-11071958 · Data updated 2026-11-12
This study is testing a new treatment to help people with chronic spinal cord injuries keep their bones strong and heal better after fractures by using a special antibody that targets specific bone cells, and it aims to make life easier and safer for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01RX004553-02 |
| Project ID | NIH-11071958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic spinal cord injuries who are at risk for bone loss and fractures.
✕Less likely to help
Patients who do not have spinal cord injuries or those with acute injuries may not benefit from this research.
What this research studies
This research investigates a new treatment approach to prevent bone loss and improve fracture healing in individuals with chronic spinal cord injury (SCI). It focuses on using an anti-Siglec-15 antibody to selectively inhibit the activity of certain bone cells involved in bone resorption, while preserving the cells that promote bone formation. By targeting this specific pathway, the research aims to enhance skeletal integrity and reduce the risk of fractures, which can significantly impact the quality of life for patients. The study will involve evaluating the safety and effectiveness of this treatment in a clinical setting.
Why it matters
Potential benefit: If successful, this research could lead to a novel therapy that significantly reduces fracture risk and improves bone health in patients with spinal cord injuries.
How similar studies have gone: While the approach of targeting Siglec-15 is relatively novel, similar strategies in bone health management have shown promise in other contexts, suggesting potential for success.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Qin, Weiping — James J Peters VA Medical Center
- Study coordinator: Qin, Weiping
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.