Improving bone healing in patients with inflammation-related fractures
Targeting angiogenesis for fracture nonunion treatment under inflammatory diseases
This study is looking at how long-lasting inflammation can make it harder for broken bones to heal properly, and it’s testing a special protein to see if it can help improve healing by boosting blood flow right at the fracture site for people dealing with inflammatory conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10654723 on NIH RePORTER |
What this research studies
This research investigates how chronic inflammation affects the healing of bone fractures that do not heal properly, known as nonunions. It focuses on the role of a specific protein, Dnmt3b, which is involved in blood vessel formation (angiogenesis) during the healing process. By delivering certain proteins directly to the fracture site, the study aims to restore blood flow and promote healing in patients suffering from inflammatory conditions. The research includes laboratory studies and may involve clinical trials to test the effectiveness of this approach in real patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals with inflammatory conditions such as rheumatoid arthritis, diabetes, or those who smoke.
Not a fit: Patients with fractures that are healing normally or those without any inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve healing outcomes for patients with difficult-to-heal fractures.
How similar studies have performed: Previous research has shown promising results in targeting angiogenesis for improving fracture healing, suggesting that this approach could be effective.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Shen, Jie — Washington University
- Study coordinator: Shen, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.