Improving bone healing in cleft palate patients using a new treatment approach
Regulating Skeletal Stem Cell and Neutrophil Dynamics for Improved Cleft Palate Bone Regeneration by Newly Designed Surrogate Bone Morphogenetic Protein-2
This study is looking at a new, less invasive treatment to help heal bone in patients with cleft lip and palate by using a special version of a protein that helps bones grow, and it aims to make recovery easier and safer for you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11054492 on NIH RePORTER |
What this research studies
This research focuses on enhancing bone regeneration in patients with cleft lip and palate by investigating a new treatment that uses a modified version of Bone Morphogenetic Protein-2 (BMP-2). The study aims to understand how this treatment interacts with skeletal stem cells and immune cells to improve healing outcomes. By addressing the limitations of current treatments, which often require invasive surgeries and have high complication rates, this research seeks to provide a less invasive alternative for patients. The approach involves detailed analysis of the mechanisms behind bone repair in different areas of the mouth, particularly the palate and mandible.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals born with cleft lip and palate who require bone regeneration treatments.
Not a fit: Patients who do not have cleft lip and palate or those who have already undergone irreversible surgical interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less invasive treatments for bone regeneration in cleft palate patients.
How similar studies have performed: Previous research has shown promise in using BMP-2 for bone regeneration, but this specific approach targeting cleft palate is novel and untested.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Takematsu, Eri — Stanford University
- Study coordinator: Takematsu, Eri
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.