Improving bone healing in cleft palate patients using a new treatment approach
Official title: Regulating Skeletal Stem Cell and Neutrophil Dynamics for Improved Cleft Palate Bone Regeneration by Newly Designed Surrogate Bone Morphogenetic Protein-2
Funded at Stanford University · NIH-11054492 · Data updated 2026-11-12
This study is looking at a new, less invasive treatment to help heal bone in patients with cleft lip and palate by using a special version of a protein that helps bones grow, and it aims to make recovery easier and safer for you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 12, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $129,420 |
| NIH project number | 1K99DE032773-01A1 |
| Project ID | NIH-11054492 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals born with cleft lip and palate who require bone regeneration treatments.
✕Less likely to help
Patients who do not have cleft lip and palate or those who have already undergone irreversible surgical interventions may not benefit from this research.
What this research studies
This research focuses on enhancing bone regeneration in patients with cleft lip and palate by investigating a new treatment that uses a modified version of Bone Morphogenetic Protein-2 (BMP-2). The study aims to understand how this treatment interacts with skeletal stem cells and immune cells to improve healing outcomes. By addressing the limitations of current treatments, which often require invasive surgeries and have high complication rates, this research seeks to provide a less invasive alternative for patients. The approach involves detailed analysis of the mechanisms behind bone repair in different areas of the mouth, particularly the palate and mandible.
Why it matters
Potential benefit: If successful, this research could lead to more effective and less invasive treatments for bone regeneration in cleft palate patients.
How similar studies have gone: Previous research has shown promise in using BMP-2 for bone regeneration, but this specific approach targeting cleft palate is novel and untested.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Takematsu, Eri — Stanford University
- Study coordinator: Takematsu, Eri
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.