Improving Bone Grafts with Engineered Tissue
Tissue Engineering Strategies to Revitalize Allografts
['FUNDING_R01'] · UNIVERSITY OF OREGON · NIH-10844524
This project is developing a new way to help bone grafts heal better for people who need bone reconstruction due to injuries, birth defects, or cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-10844524 on ClinicalTrials.gov |
What this research studies
Many people need bone grafts to fix problems from injuries, birth defects, or cancer, but current options like donor bone often don't heal as well as a patient's own bone. This happens because donor bone lacks a special outer layer called the periosteum, which is crucial for healing. Our team is creating an "engineered periosteum" using special cells and a gel-like material to wrap around donor bone grafts. We hope this new approach will help the donor bone integrate and heal much more effectively with the patient's body.
Who could benefit from this research
Good fit: This research is relevant for patients who require bone reconstruction due to congenital anomalies, trauma, infection, or cancer removal.
Not a fit: Patients who do not require bone grafts or who are able to use their own bone for grafting may not directly benefit from this specific advancement.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the failure rate of bone grafts, leading to stronger, more lasting repairs for patients with bone defects.
How similar studies have performed: Previous work by this team has shown promising results in animal models, suggesting this tissue-engineered approach can significantly enhance bone graft healing.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BENOIT, DANIELLE S. — UNIVERSITY OF OREGON
- Study coordinator: BENOIT, DANIELLE S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.