Improving body clocks to help prevent Alzheimer's disease
Optimized Circadian Rhythms for the Prevention of Alzheimer's Disease
This study is looking at how changes in our body clocks might play a role in Alzheimer's disease, using fruit flies to see if getting their eating habits in sync with day and night can help keep them healthier and possibly slow down the disease, which could lead to new ideas for helping people at risk for Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-10875730 on NIH RePORTER |
What this research studies
This research investigates how disruptions in our natural body clocks, known as circadian rhythms, may contribute to the development of Alzheimer's disease. By studying fruit flies, researchers will explore the connection between circadian rhythm disruption and Alzheimer's pathology, aiming to understand how restoring these rhythms could delay the onset and progression of the disease. The study will utilize time-restricted feeding to help synchronize the flies' feeding patterns with daylight hours, which may improve their overall health and function. The findings could provide insights into potential interventions for humans at risk of Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk for Alzheimer's disease or have early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those who do not have any circadian rhythm disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease through lifestyle changes that optimize circadian rhythms.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in various health conditions, suggesting that this approach may yield valuable insights for Alzheimer's prevention.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Panda, Satchidananda — Salk Institute for Biological Studies
- Study coordinator: Panda, Satchidananda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.