Improving blood vessel grafts for heart surgery
Transcriptomics of adherent endothelial cells for improved endothelialization of small-diameter vascular grafts
This study is looking to make heart surgery safer by using your own cells to create a natural layer on small blood vessels, which can help prevent problems like blood clots for patients who don’t have good veins for grafting.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11008921 on NIH RePORTER |
What this research studies
This research aims to create a natural layer of endothelial cells on the surfaces of small-diameter vascular grafts used in heart surgeries. By doing so, it seeks to enhance the compatibility of these grafts with blood flow, reducing the risks of complications such as blood clots and embolisms. The approach involves using patients' own cells to develop this endothelial layer, which could lead to safer and more effective surgical outcomes. The study addresses a significant clinical need, especially for patients who lack suitable veins for grafting due to various health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with coronary heart disease who need bypass surgery but do not have suitable autologous vessels available.
Not a fit: Patients who have no need for vascular grafts or those who are not undergoing heart surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer heart surgeries with improved outcomes for patients requiring vascular grafts.
How similar studies have performed: Previous research has shown promise in using autologous endothelial cells for improving graft compatibility, indicating that this approach has potential based on earlier successes.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Tefft, Brandon J — Medical College of Wisconsin
- Study coordinator: Tefft, Brandon J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.