Improving blood vessel function in veterans with heart failure
Novel Approaches for Improving Vascular Function in Veterans with HFpEF
This study is looking at how inflammation and blood vessel health impact exercise ability in veterans with heart failure, and it aims to find ways to improve their physical fitness through specific medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10980517 on NIH RePORTER |
What this research studies
This research investigates how inflammation and vascular health affect exercise tolerance in veterans suffering from heart failure with preserved ejection fraction (HFpEF). It aims to identify mechanisms that contribute to vascular dysfunction and explore targeted pharmacologic interventions to enhance physical capacity. The study will utilize a randomized, double-blind, crossover design to assess the effectiveness of these interventions on improving vascular function and overall health. Participants will engage in a series of experiments designed to measure changes in their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans diagnosed with heart failure with preserved ejection fraction (HFpEF).
Not a fit: Patients without a diagnosis of heart failure or those with heart failure with reduced ejection fraction (HFrEF) may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved physical capacity and quality of life for veterans with HFpEF.
How similar studies have performed: Previous research has shown promising results in addressing vascular dysfunction in heart failure patients, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
Salt Lake City, United States
- VA Salt Lake City Healthcare System — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Wray, D. Walter — VA Salt Lake City Healthcare System
- Study coordinator: Wray, D. Walter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.