Improving blood vessel formation for heart disease treatment
Vascular Regeneration with Direct Reprogramming and Engineering Strategies
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10892050
This study is looking at new ways to help people with heart problems caused by poor blood flow by using their own cells to create new blood vessels, making treatments safer and more effective.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10892050 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new methods to regenerate blood vessels in patients with ischemic cardiovascular diseases, which are conditions caused by reduced blood flow. The approach involves directly reprogramming patients' own cells into endothelial cells, which are crucial for blood vessel formation, using specific transcription factors. By utilizing a safer delivery method for these reprogrammed cells, the research aims to enhance the effectiveness of cell-based therapies and improve patient outcomes. The study also explores bioengineered solutions to ensure the survival of these transplanted cells in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from ischemic cardiovascular diseases who may benefit from improved blood vessel regeneration.
Not a fit: Patients with non-ischemic cardiovascular conditions or those who do not have significant blood vessel dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore blood flow and improve heart function in patients with cardiovascular diseases.
How similar studies have performed: Other research has shown promise in using direct reprogramming techniques for cell therapy, indicating potential success for this novel approach.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YOON, YOUNG-SUP — EMORY UNIVERSITY
- Study coordinator: YOON, YOUNG-SUP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.