Improving blood vessel formation for better heart health
Official title: Modulating the resolution of angiogenesis and normalization of the vasculature for therapeutic benefit
Funded at University of Maryland Baltimore · NIH-11046204 · Data updated 2026-11-12
This study is looking at ways to help your body grow new blood vessels to improve blood flow and healing in areas affected by heart problems, so you can feel better and recover faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $549,665 |
| NIH project number | 1R01HL172364-01A1 |
| Project ID | NIH-11046204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with ischemic peripheral artery diseases or other cardiovascular disorders that involve impaired blood flow.
✕Less likely to help
Patients with non-cardiovascular conditions or those whose vascular issues are not related to angiogenesis may not benefit from this research.
What this research studies
This research focuses on understanding and improving the process of angiogenesis, which is the formation of new blood vessels, particularly in patients with cardiovascular diseases. By investigating how to effectively control and resolve angiogenesis, the study aims to enhance blood flow to tissues that have been deprived of oxygen due to blocked arteries. The approach includes exploring various therapeutic methods, such as gene delivery and the use of growth factors, to promote healthy blood vessel formation and repair. Patients may benefit from new treatments that restore blood supply and improve healing in ischemic tissues.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients suffering from cardiovascular diseases, improving their quality of life and reducing complications.
How similar studies have gone: Previous research has shown mixed results in angiogenesis therapies, indicating that while the approach is promising, it requires further exploration and understanding.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Antalis, Toni M — University of Maryland Baltimore
- Study coordinator: Antalis, Toni M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.