Improving blood vessel and muscle repair for patients with severe limb ischemia
Official title: BCCMA: Vascular Regeneration for PAD: Therapeutic Delivery of Angiogenic Stem Cells and mRNA-Based Gene Therapy
Funded at Veterans Admin Palo Alto Health Care Sys · NIH-11051527 · Data updated 2026-11-12
This study is exploring new ways to help people with chronic limb threatening ischemia (CLTI) by using special cell therapies and materials to improve blood vessel and muscle healing, with the goal of reducing the need for amputations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | April 1, 2025 |
| Project end | September 30, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01BX006882-01 |
| Project ID | NIH-11051527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic limb threatening ischemia who are at risk of amputation.
✕Less likely to help
Patients with non-vascular related conditions or those not diagnosed with chronic limb threatening ischemia may not benefit from this research.
What this research studies
This research focuses on developing innovative therapies to enhance blood vessel and muscle repair in patients suffering from chronic limb threatening ischemia (CLTI). The approach involves using advanced cell therapies combined with biomaterials to improve the delivery and effectiveness of therapeutic cells. By testing new cell types and delivery methods, the research aims to reduce the need for amputations in affected patients. Additionally, new imaging techniques will be employed to better select the most effective treatments for individuals with CLTI.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of amputations in patients with severe limb ischemia.
How similar studies have gone: Previous research has shown promise in using cell therapies and biomaterials for vascular repair, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Veterans Admin Palo Alto Health Care Sys
Palo Alto, United States Active
Researchers
- Principal investigator: Huang, Ngan F. — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Huang, Ngan F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.