Improving blood sugar control during exercise for people with Type 1 diabetes

Limiting Dysglycemia Around Physical Activity for People with Type 1 Diabetes Using Activity-Aware Automated Insulin Delivery – the APEX Project.

NIH-funded research University of Virginia · NIH-11135506

This research aims to help people with Type 1 diabetes manage their blood sugar better when they are physically active, using a smart insulin delivery system.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Virginia NIH-funded
Lab location1 site (Charlottesville, United States)
Project IDNIH-11135506 on NIH RePORTER

What this research studies

Many people with Type 1 diabetes find it challenging to exercise due to worries about low blood sugar or the need for careful planning. This research is developing new ways for an automated insulin delivery system, called APEX, to adjust insulin automatically before, during, and after physical activity. It considers how insulin sensitivity changes after exercise, the lasting effects of previous activity, and even predicts future activity patterns. The goal is to make it easier for you to be spontaneous with your exercise without constantly thinking about your insulin.

Who could benefit from this research

Good fit: Ideal candidates would be individuals with Type 1 diabetes who use or are candidates for automated insulin delivery systems and engage in physical activity.

Not a fit: Patients who do not have Type 1 diabetes or do not use automated insulin delivery systems would not directly benefit from this specific technology.

Why it matters

Potential benefit: If successful, this could allow people with Type 1 diabetes to exercise more freely and safely, improving their overall health and quality of life.

How similar studies have performed: This project tests novel approaches within an existing, well-established automated insulin delivery system developed by a center with a strong track record in diabetes technology and clinical trials.

Where this research is happening

Charlottesville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Brittle Diabetes Mellitus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.