Improving blood sample processing to better analyze immune responses in cancer treatment
Optimization of peripheral blood mononuclear cell (PBMC) processing for robust downstream functional immune cell analysis and correlation with therapeutic efficacy
This study is looking at how to better use blood samples to understand how your immune system responds to cancer treatments, making it easier to find out how well those treatments might work for you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11049146 on NIH RePORTER |
What this research studies
This research focuses on enhancing the processing of peripheral blood mononuclear cells (PBMCs) to improve the analysis of immune cell functions related to cancer therapies. By using blood samples instead of traditional tissue biopsies, which can be difficult to obtain, the study aims to develop reliable biomarkers that can predict how well patients respond to anti-cancer treatments. The researchers will implement rigorous techniques to ensure the viability of these blood samples, allowing for more accurate assessments of the immune response during and after treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment for solid tumors who require monitoring of their immune response.
Not a fit: Patients with blood disorders or those who cannot provide blood samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring of cancer treatment responses and better personalized therapy options for patients.
How similar studies have performed: Previous research has shown promise in using blood-based biomarkers for monitoring cancer therapies, indicating that this approach could be effective.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wise-Draper, Trisha M — University of Cincinnati
- Study coordinator: Wise-Draper, Trisha M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.