Improving blood flow recovery in older adults with targeted therapies
Official title: Combining Targeted Demethylation with Noncoding RNA-mediated mRNA Stabilization as a Strategy for Therapeutic Arteriogenesis in the Aged
Funded at Ocean State Research Institute, INC. · NIH-11056889 · Data updated 2026-11-12
This study looks at how getting older affects our body's ability to improve blood flow after an injury, especially for people with peripheral artery disease, and it focuses on a protein that helps with blood vessel growth and repair, with the goal of finding better treatments to help older adults recover more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ocean State Research Institute, INC. NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $462,403 |
| NIH project number | 5R01HL163005-04 |
| Project ID | NIH-11056889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing conditions related to poor blood flow, such as peripheral artery disease.
✕Less likely to help
Patients who are younger or do not have age-related vascular conditions may not benefit from this research.
What this research studies
This research investigates how aging affects the body's ability to recover blood flow after injury, particularly in conditions like peripheral artery disease. It focuses on a specific protein, HuR, that stabilizes mRNA necessary for blood vessel growth and repair. By understanding the mechanisms that lead to reduced effectiveness in older individuals, the researchers aim to develop targeted therapies that can enhance blood flow recovery. The study uses animal models to explore the effects of certain genetic and molecular changes associated with aging.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce complications from age-related vascular diseases.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for improving vascular health in aging populations, suggesting potential for success in this approach.
Where this research is happening
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Ocean State Research Institute, INC.
Providence, United States Active
Researchers
- Principal investigator: Morrison, Alan Ross — Ocean State Research Institute, INC.
- Study coordinator: Morrison, Alan Ross
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.