Improving blood flow in the brain to support memory and thinking in Alzheimer's disease
Rescuing neurovascular coupling to protect neuronal plasticity and cognition
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10530887
This study is looking at how blood flow changes in the brain can affect thinking and memory in people with Alzheimer's and similar conditions, and it aims to find ways to improve blood flow and boost brain function using new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10530887 on ClinicalTrials.gov |
What this research studies
This research investigates how changes in blood flow in the brain contribute to cognitive decline in Alzheimer's disease and related dementias. It focuses on understanding the mechanisms behind neurovascular coupling, which is the process that ensures adequate blood supply to active brain regions. By using advanced imaging techniques and therapeutic approaches, the study aims to restore proper blood flow and improve cognitive functions in affected individuals. The research involves both patient observations and mouse models to explore the effectiveness of new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias who are experiencing cognitive decline.
Not a fit: Patients with other types of dementia not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance cognitive function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in restoring neurovascular coupling in animal models, indicating potential for success in human applications.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DELL'ACQUA, MARK L — UNIVERSITY OF COLORADO DENVER
- Study coordinator: DELL'ACQUA, MARK L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease