Improving blood-flow diversion devices for brain aneurysms
Computational and Biological Approach to Flow Diversion
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11238931
Working to make flow-diverting devices safer and usable for more people with brain aneurysms, including those with ruptured or distant aneurysms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11238931 on ClinicalTrials.gov |
What this research studies
Researchers will combine advanced computer models of blood flow with biological studies and special imaging to learn how flow-diverting devices help aneurysms heal and when they block nearby arteries. They'll use in‑vivo fibrin molecular imaging, computational fluid dynamics, and animal models to study clot formation, endothelial growth, device fit, and blood-flow forces. They plan to identify what increases the risk of thromboembolic complications so doctors can tailor treatment to each person. The goal is to support development of next‑generation devices and personalized approaches that could be offered to patients in future trials.
Who could benefit from this research
Good fit: People with intracranial aneurysms being considered for flow-diverter treatment—including some with ruptured aneurysms or aneurysms located distal to the main arteries—would be the target group.
Not a fit: People without intracranial aneurysms or those who are not candidates for endovascular procedures are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could expand safe use of flow-diverters to more aneurysm types and reduce clot-related complications through more personalized device choices.
How similar studies have performed: Current flow-diverter devices already treat many unruptured aneurysms successfully, but expanding to ruptured or distal aneurysms and reducing clot-related complications is still a newer and active area of research.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KADIRVEL, RAMANATHAN — MAYO CLINIC ROCHESTER
- Study coordinator: KADIRVEL, RAMANATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.