Improving blood flow and metabolism in Alzheimer's disease models
Modulating blood flow and metabolism in Alzheimer's Disease models
This study is looking at a gentle method called gamma entrainment, which uses sound and light to help improve brain function in Alzheimer's disease, and it's testing this on mice to see how it affects blood flow and energy in the brain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11190786 on NIH RePORTER |
What this research studies
This research focuses on using advanced microscopy techniques to explore the effects of gamma entrainment, a non-invasive method that uses sensory stimuli to potentially improve brain function in Alzheimer's disease. By applying this technique in mouse models, the researchers aim to understand how it influences blood flow and energy metabolism in the brain. The study seeks to optimize the parameters of gamma entrainment to enhance its effectiveness in reducing cognitive decline and amyloid levels, which are associated with Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new non-pharmacological treatments that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results with similar neuromodulation techniques in animal models and some human patients, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Yaseen, Mohammad Abbas — Northeastern University
- Study coordinator: Yaseen, Mohammad Abbas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.