Improving Blood Clot Prevention for Medical Devices
Contact Pathway Activation on Vascular Devices
This project looks for new ways to prevent dangerous blood clots from forming on medical devices inside the body, aiming for treatments that cause less bleeding.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11109658 on NIH RePORTER |
What this research studies
This project explores how a specific blood clotting process, called contact activation, contributes to clots forming on medical devices like stents and oxygenators. Current clot-preventing medicines, while helpful, often lead to serious bleeding, especially in vulnerable patients like sick newborns on life support. We are working to understand this clotting pathway better to develop new medicines that are safer and cause fewer bleeding side effects. Our goal is to create better ways to protect patients with medical devices from both clotting and bleeding complications.
Who could benefit from this research
Good fit: Patients who rely on vascular medical devices such as stents, grafts, hemodialyzers, or ECMO, and are at risk for blood clots and bleeding complications, could potentially benefit from this research.
Not a fit: Patients who do not have medical devices that interact with the blood or are not at risk for device-related blood clots would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new anticoagulant medications that are more effective at preventing clots on medical devices while significantly reducing the risk of dangerous bleeding.
How similar studies have performed: While current antithrombotic drugs exist, this research focuses on a novel approach to develop safer options with fewer bleeding side effects, addressing an unmet medical need.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mccarty, Owen J — Oregon Health & Science University
- Study coordinator: Mccarty, Owen J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.