Improving blood clot clearance after brain hemorrhage in infants
Official title: Harnessing blood clot clearance mechanisms after germinal matrix hemorrhage
Funded at Loma Linda University · NIH-10993610 · Data updated 2026-11-12
This study is looking at ways to help preterm babies recover from blood clots that can happen after a type of brain bleed, with the hope of improving their brain health and reducing complications like fluid buildup in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | February 1, 2021 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $355,500 |
| NIH project number | 5R01NS117364-05 |
| Project ID | NIH-10993610 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are preterm infants who have experienced germinal matrix hemorrhage.
✕Less likely to help
Patients who are not preterm or who have not experienced germinal matrix hemorrhage may not benefit from this research.
What this research studies
This research investigates how to enhance the body's ability to clear blood clots that form after germinal matrix hemorrhage (GMH) in preterm infants. By focusing on the role of specific receptors and proteins involved in the inflammatory response and blood clot resolution, the study aims to improve neurological outcomes and reduce complications such as hydrocephalus. The approach includes examining the activation of receptors that promote the clearance of blood clots and the subsequent effects on brain health. The findings could lead to new therapeutic strategies for managing GMH.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery and reduce long-term complications for infants affected by brain hemorrhage.
How similar studies have gone: Other research has shown promise in enhancing blood clot clearance mechanisms, suggesting that this approach could lead to meaningful advancements in treatment.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Tang, Jiping — Loma Linda University
- Study coordinator: Tang, Jiping
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
-
SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Statin use after brain bleed: SATURN MRI ancillary study
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
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Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
-
Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.