Improving Blood and Marrow Transplants for Older Adults
BMT Core - Johns Hopkins
This program aims to make blood and marrow transplantation safer and more effective, especially for older patients with blood cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11164551 on NIH RePORTER |
What this research studies
This program at Johns Hopkins focuses on making blood and marrow transplantation (BMT) better for patients. A key success has been developing a method called post-transplant cyclophosphamide (PTCy) to prevent graft-versus-host disease (GVHD), which allows more people to receive life-saving transplants, even with mismatched donors. The team is now working to improve BMT outcomes specifically for older patients, as traditional risk assessments don't work as well for them. They are looking into new ways to reduce transplant-related side effects in this age group, with a particular focus on those over 70.
Who could benefit from this research
Good fit: Patients who are 65 or older and need a blood and marrow transplant for a hematologic malignancy might be ideal candidates for future related studies.
Not a fit: Patients who do not require a blood and marrow transplant or are not in the older age group may not directly benefit from this specific focus.
Why it matters
Potential benefit: If successful, this work could make blood and marrow transplantation safer and more widely available, especially for older patients with blood cancers.
How similar studies have performed: The development of post-transplant cyclophosphamide (PTCy) has already been established as a new standard of care in a large, multi-institutional trial, demonstrating success with this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Jones, Richard J — Johns Hopkins University
- Study coordinator: Jones, Richard J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.