Improving B cells to better control HIV
Engineering B cells for enhanced HIV control
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11009399
This study is looking at a way to help your body's B cells make special antibodies that can fight HIV better, using a technique called CRISPR to give them a boost, so they can work more effectively even when T cells are not as supportive.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11009399 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the ability of B cells to produce antibodies that can effectively control HIV. By using CRISPR gene editing, the researchers aim to engineer B cells to secrete custom antibodies known as broadly neutralizing antibodies (bnAbs). These engineered B cells could act as living drugs, responding to HIV and providing a more effective immune response. The project also seeks to address the challenges faced by B cells in individuals living with HIV, particularly their need for support from T cells to function properly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may benefit from enhanced immune responses.
Not a fit: Patients who are not living with HIV or those who have advanced stages of the disease with no viable immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel therapy that significantly improves the immune response against HIV in patients.
How similar studies have performed: Other research has shown promise in using gene editing and engineered immune cells for various conditions, indicating potential for success in this novel approach.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATHUR, ATISHAY — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: MATHUR, ATISHAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus