Improving asthma treatment by targeting beta2-adrenoceptors
Allosteric modulation of beta2- adrenoceptors in the treatment of asthma
This study is looking for ways to make asthma medications work better and longer by finding new ways to help them open up your airways, so you can breathe easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11059850 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of beta2-adrenergic receptor agonists, which are commonly used medications for asthma. It aims to address the limitations of these medications, such as reduced efficacy over time and worsening symptoms. By utilizing advanced computational methods, the study seeks to identify new conformations and allosteric sites on the beta2-adrenoceptors, allowing for the development of novel ligands that can promote beneficial signaling in the airways. This approach could lead to improved bronchodilation and overall asthma management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with asthma who are currently using beta2-agonists but experience limited effectiveness or side effects.
Not a fit: Patients who do not have asthma or those who are not using beta2-agonists may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective asthma treatments with fewer side effects.
How similar studies have performed: Previous research has shown promise in targeting allosteric sites on receptors for improved therapeutic outcomes, indicating potential success for this approach.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Deshpande, Deepak a — Thomas Jefferson University
- Study coordinator: Deshpande, Deepak a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.