Improving asthma treatment by targeting beta2-adrenoceptors
Official title: Allosteric modulation of beta2- adrenoceptors in the treatment of asthma
Funded at Thomas Jefferson University · NIH-11059850 · Data updated 2026-11-12
This study is looking for ways to make asthma medications work better and longer by finding new ways to help them open up your airways, so you can breathe easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $509,870 |
| NIH project number | 5R01HL173113-02 |
| Project ID | NIH-11059850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with asthma who are currently using beta2-agonists but experience limited effectiveness or side effects.
✕Less likely to help
Patients who do not have asthma or those who are not using beta2-agonists may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of beta2-adrenergic receptor agonists, which are commonly used medications for asthma. It aims to address the limitations of these medications, such as reduced efficacy over time and worsening symptoms. By utilizing advanced computational methods, the study seeks to identify new conformations and allosteric sites on the beta2-adrenoceptors, allowing for the development of novel ligands that can promote beneficial signaling in the airways. This approach could lead to improved bronchodilation and overall asthma management.
Why it matters
Potential benefit: If successful, this research could lead to more effective asthma treatments with fewer side effects.
How similar studies have gone: Previous research has shown promise in targeting allosteric sites on receptors for improved therapeutic outcomes, indicating potential success for this approach.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Deshpande, Deepak a — Thomas Jefferson University
- Study coordinator: Deshpande, Deepak a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.