Improving artificial blood vessels using stem cells
Preclinical Optimization and Design for Manufacturability of Immunoregulatory TEVGs
This study is working on creating new artificial blood vessels that use special cells to help them heal better and fit into your body, with the hope of offering a safer option for people who need surgery to bypass blocked arteries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11040123 on NIH RePORTER |
What this research studies
This research focuses on developing advanced artificial blood vessels, known as tissue-engineered vascular grafts (TEVGs), that utilize the regenerative properties of stem cells. The team aims to enhance these grafts by incorporating factors secreted by mesenchymal stem/stromal cells (MSCs) to improve healing and integration within the body. Through a series of laboratory tests, they will evaluate the effectiveness of these grafts in promoting new blood vessel formation and reducing complications. The ultimate goal is to prepare these grafts for clinical use, potentially offering a new option for patients needing arterial bypass surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring arterial bypass surgery who may benefit from improved graft options.
Not a fit: Patients who do not require arterial bypass surgery or have contraindications for vascular grafts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with safer and more effective alternatives to traditional vein or artery grafts for bypass surgeries.
How similar studies have performed: Previous research has shown promise in using stem cells for vascular grafts, indicating potential for success in this innovative approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Vorp, David Alan — University of Pittsburgh at Pittsburgh
- Study coordinator: Vorp, David Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.