Improving Arteriovenous Fistulas for Dialysis
Manipulating the matrix to improve arteriovenous fistula patency
This research explores ways to help arteriovenous fistulas (AVFs) work better and last longer for people who need hemodialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11141596 on NIH RePORTER |
What this research studies
Many people who need hemodialysis rely on an arteriovenous fistula (AVF), which is a connection between an artery and a vein, to access their blood. However, these fistulas often don't mature properly or fail over time, especially in women, leading to more surgeries. Our team is working to understand the natural processes that help veins adapt to the high blood flow of an AVF. We are looking at specific biological signals, like TGF-beta and a protein called tenascin-C, that influence how the vein wall remodels. By understanding these signals, we hope to find new ways to make AVFs more successful and durable for patients.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with kidney failure who require hemodialysis and rely on arteriovenous fistulas for vascular access.
Not a fit: Patients who do not require hemodialysis or do not use an arteriovenous fistula for vascular access would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help AVFs mature better and last longer, reducing the need for repeated procedures and improving the quality of life for dialysis patients.
How similar studies have performed: This research uses an innovative mouse model and has generated exciting new data, suggesting a novel approach to understanding and improving AVF patency.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Dardik, Alan — Yale University
- Study coordinator: Dardik, Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.