Improving antibody responses to HIV using immune complex vaccines
Using immune complex vaccines to optimize antibody responses to HIV Env
This study is looking at how a special type of vaccine can help the body make stronger and more effective antibodies against HIV, and it's being tested in mice to see if it can lead to a better vaccine for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11035167 on NIH RePORTER |
What this research studies
This research investigates how immune complex vaccines can enhance the body's antibody responses to the HIV envelope protein. By combining HIV Env with specific anti-Env monoclonal antibodies, the study aims to modify the immune response to produce more effective antibodies against various strains of HIV. The approach involves immunizing mice to observe how these immune complexes influence the specificity and strength of the antibody responses generated. The ultimate goal is to develop a vaccine that can elicit broadly neutralizing antibodies against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals at high risk for HIV infection or those who are HIV-positive and seeking improved treatment options.
Not a fit: Patients who are not at risk for HIV or those who are already effectively managing their HIV with existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective HIV vaccine that generates stronger and more broadly reactive antibody responses.
How similar studies have performed: Previous studies have shown promise in using immune complexes to direct antibody responses, indicating that this approach may lead to significant advancements in HIV vaccine development.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Hioe, Catarina E — Icahn School of Medicine at Mount Sinai
- Study coordinator: Hioe, Catarina E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.