Improving antibiotics to fight resistant bacterial infections
Use of De Novo Synthesis Approaches and Structure-guided Design to Optimize Therapeutic Properties of Streptothricin Class Antimicrobials
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10907622
This study is looking at a natural substance called streptothricin to create new antibiotics that can help fight tough infections caused by bacteria that don't respond to regular treatments, so patients can have better options when dealing with these hard-to-treat infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10907622 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new antibiotics to combat the growing problem of antibiotic resistance, particularly against dangerous bacteria like Acinetobacter baumannii. The team is investigating a natural product called streptothricin, which has shown promise in laboratory tests for its ability to inhibit the growth of multidrug-resistant bacteria. By modifying the structure of streptothricin, the researchers aim to enhance its effectiveness while reducing potential side effects. Patients may benefit from new treatment options that are effective against infections that currently have limited treatment alternatives.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by multidrug-resistant bacteria, particularly those infected with Acinetobacter baumannii.
Not a fit: Patients with infections caused by bacteria that are not resistant to current antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antibiotics that effectively treat infections caused by resistant bacteria.
How similar studies have performed: Previous research has shown promise in developing new antibiotics using similar approaches, indicating potential for success in this area.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIRBY, JAMES E — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: KIRBY, JAMES E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.