Improving antibiotic use to prevent surgical site infections

Targeting Surgical Site Infections through a Perioperative Antibiotic Clinical Decision Support Tool

['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10886594

This study is working on a helpful tool for surgeons to make sure patients get the right antibiotics during surgery, which can help prevent infections and improve recovery for everyone, especially in unexpected surgery situations.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorMASSACHUSETTS GENERAL HOSPITAL (nih funded)
Locations1 site (BOSTON, UNITED STATES)
Trial IDNIH-10886594 on ClinicalTrials.gov

What this research studies

This research focuses on reducing the incidence of surgical site infections (SSIs) by developing a clinical decision support tool for perioperative antibiotic administration. It aims to enhance adherence to the more comprehensive guidelines set by the Infectious Disease Society of America (IDSA), which include specific antibiotic selection, weight-adjusted dosing, and timely re-dosing during surgeries. By analyzing data from surgical cases, the project seeks to identify and address gaps in current practices, especially in unplanned surgical scenarios. The goal is to provide surgeons with better tools to make informed decisions about antibiotic use, ultimately improving patient outcomes.

Who could benefit from this research

Good fit: Ideal candidates for this research are patients undergoing surgical procedures who are at risk for surgical site infections.

Not a fit: Patients who are not undergoing surgery or those who do not require antibiotic prophylaxis may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly reduce the rates of surgical site infections, leading to better patient outcomes and lower healthcare costs.

How similar studies have performed: Previous research has shown that improved adherence to comprehensive antibiotic guidelines can lead to reduced infection rates, indicating potential success for this approach.

Where this research is happening

BOSTON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.