Improving Antibiotic Use for Breastfeeding Mothers and Their Babies
Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
This research aims to understand how antibiotics given to breastfeeding mothers affect their infants' health, especially their gut bacteria and immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11143898 on NIH RePORTER |
What this research studies
When breastfeeding mothers take antibiotics, we want to understand how much of the medicine reaches their babies through breast milk or close contact. This project looks at how these antibiotics might impact the baby's developing gut microbiome, which is the community of helpful bacteria in their digestive system, and their overall immune function. We are also exploring how breast milk itself, with its beneficial components, might protect the baby's gut health even when antibiotics are present. Our goal is to find the best ways to use antibiotics in mothers to keep both mother and baby healthy.
Who could benefit from this research
Good fit: Ideal candidates would be breastfeeding mothers who need antibiotic treatment and their infants.
Not a fit: Patients who are not breastfeeding or whose infants are not exposed to maternal antibiotics would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to safer and more effective antibiotic guidelines for breastfeeding mothers, protecting infant health while ensuring mothers receive necessary treatment.
How similar studies have performed: While the general topic of maternal-infant pharmacology is established, this project uses advanced pharmacomicrobiomic and metabolomic analyses to explore novel aspects of antibiotic impact on the infant microbiome and immune system.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Tremoulet, Adriana H — University of California, San Diego
- Study coordinator: Tremoulet, Adriana H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.