Improving antibiotic selection for abdominal and skin infections
INSPIRE (INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients): The INSPIRE-ASP Trial for Intra-Abdominal and Skin and Soft Tissue Infections
The INSPIRE-ASP Trial is testing a new way to help doctors choose the best antibiotics for patients in the hospital with belly or skin infections, using smart tools to see if the infection might be resistant to treatment, so they can avoid using stronger antibiotics when they’re not needed.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Pilgrim Health Care, INC. NIH-funded |
| Lab location | 1 site (Canton, UNITED STATES) |
| Project ID | NIH-10840313 on NIH RePORTER |
What this research studies
The INSPIRE-ASP Trial aims to enhance antibiotic prescribing practices for hospitalized patients with abdominal infections or skin and soft tissue infections. By utilizing a predictive algorithm that assesses each patient's likelihood of having an antibiotic-resistant infection, the trial seeks to guide physicians in choosing the most appropriate antibiotics. This approach is based on data collected from electronic health records and local resistance patterns. The trial will compare standard care with an enhanced program that includes feedback and audits to minimize unnecessary use of broad-spectrum antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research are non-critically ill hospitalized patients diagnosed with abdominal infections or skin and soft tissue infections.
Not a fit: Patients who are critically ill or have infections caused by antibiotic-resistant pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted antibiotic treatments, reducing the risk of antibiotic resistance and improving patient outcomes.
How similar studies have performed: Previous research has shown that similar antibiotic stewardship programs can effectively reduce unnecessary antibiotic use, suggesting a promising outcome for this trial.
Where this research is happening
Canton, UNITED STATES
- Harvard Pilgrim Health Care, INC. — Canton, United States (Active)
Researchers
- Principal investigator: Platt, Richard — Harvard Pilgrim Health Care, INC.
- Study coordinator: Platt, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.