Improving analysis of important biological molecules called glycosaminoglycans
Development of solid-state nanopore technology for improved glycosaminoglycan analytics
This study is working on a new way to measure important molecules called glycosaminoglycans, like hyaluronan, which can help us understand and track certain diseases better, making it easier for doctors to analyze small samples from patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10999932 on NIH RePORTER |
What this research studies
This research focuses on enhancing the analysis of glycosaminoglycans (GAGs), which are crucial biological molecules. The team has developed solid-state nanopore technology to measure the molecular weight and abundance of hyaluronan, a specific type of GAG, from small biological samples. The project aims to create a more versatile tool for GAG analysis by integrating quantification methods and establishing a microfluidic system for easier extraction and analysis. This advancement could lead to better understanding and monitoring of various diseases where GAGs play a role.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions linked to glycosaminoglycan abnormalities, such as certain cancers or inflammatory diseases.
Not a fit: Patients without any known issues related to glycosaminoglycans or those not diagnosed with relevant conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more accurate diagnostic tools for diseases associated with glycosaminoglycans, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using nanopore technology for biomolecule analysis, indicating potential success for this novel approach.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Hall, Adam Roger — Wake Forest University Health Sciences
- Study coordinator: Hall, Adam Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.