Improving a New Treatment for Preeclampsia
Restoration of reduced nitric oxide bioavailability in Preeclampsia
This work aims to create a better version of a promising new medication to help mothers with preeclampsia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11170574 on NIH RePORTER |
What this research studies
Preeclampsia is a serious pregnancy complication causing high blood pressure and kidney problems. Our lab has found a medication, AKT-1005, that shows good results in early tests for preeclampsia. However, AKT-1005 is hard to use because it doesn't dissolve well in water and isn't very stable. This project focuses on making new, improved versions of AKT-1005 that are easier to use and more effective, which will then be tested in animal models of preeclampsia.
Who could benefit from this research
Good fit: This foundational work is for patients interested in the development of new treatments for preeclampsia.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this work could lead to a more effective and safer treatment option for preeclampsia, potentially improving outcomes for mothers and babies.
How similar studies have performed: Initial studies have shown beneficial effects of the original compound in laboratory and animal models of preeclampsia, suggesting a promising approach.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Zsengeller, Zsuzsanna Kinga — Beth Israel Deaconess Medical Center
- Study coordinator: Zsengeller, Zsuzsanna Kinga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.