Improving a gene therapy for treating glioblastoma
Official title: Improving IL12 Immunogene Therapy for Glioblastoma Based on Human Clinical Trial Results
Funded at Brigham and Women's Hospital · NIH-10977809 · Data updated 2026-11-12
This study is looking at a new way to help the immune system fight glioblastoma, a tough type of brain cancer, by using a special gene therapy and combining it with other treatments to make it work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 22, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $633,656 |
| NIH project number | 1R01NS134723-01A1 |
| Project ID | NIH-10977809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with recurrent glioblastoma who have not responded well to standard treatments.
✕Less likely to help
Patients with glioblastoma who are in the early stages of the disease or those who have already undergone extensive treatment may not benefit from this research.
What this research studies
This research focuses on enhancing a specific gene therapy that targets glioblastoma, a highly aggressive brain cancer. The approach involves directly administering a therapy that activates the immune system within the tumor, aiming to overcome the cancer's ability to evade immune responses. Previous clinical trials have shown promising results in increasing immune cell infiltration in tumors, but challenges remain due to the tumor's immunosuppressive environment. The research will explore combining this therapy with immune checkpoint inhibitors to improve treatment outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with glioblastoma, potentially improving survival rates.
How similar studies have gone: Previous clinical trials using similar gene therapy approaches have shown promising results, indicating potential for success in this novel combination strategy.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chiocca, E. Antonio — Brigham and Women's Hospital
- Study coordinator: Chiocca, E. Antonio
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.