Improving a calcium sensor to record brain activity in moving mice
Optimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice
This study is testing a new tool to help scientists see how brain cells work together in mice that can move around freely, which could help us learn more about how the brain functions and changes as we age.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11010878 on NIH RePORTER |
What this research studies
This research focuses on enhancing a specialized calcium ion sensor called CaMPARI to monitor the activity of brain cells in freely-moving mice. By utilizing advanced imaging techniques, the study aims to capture the synchronized activity of neurons across different brain regions, which is crucial for understanding complex behaviors. The researchers will optimize the sensor's ability to provide both permanent and dynamic measurements of neuronal activity without the need for invasive devices. This innovative approach could lead to significant advancements in our understanding of brain function and age-related changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the effects of aging on brain function and those with age-related neurological conditions.
Not a fit: Patients with acute neurological injuries or conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding how brain activity changes with age, potentially informing treatments for age-related neurological conditions.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for monitoring brain activity, indicating that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dana, Hod Michael — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dana, Hod Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.