Improving 3D imaging techniques for biological structures
Official title: Multi-Resolution Docking Methods for Electron Microscopy
Funded at Old Dominion University · NIH-10842834 · Data updated 2026-11-12
This study is working on improving a special imaging technique called cryo-electron microscopy to help scientists see the shapes of tiny biological molecules better, which could lead to more effective medicines for various diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $396,292 |
| NIH project number | 1R35GM153431-01 |
| Project ID | NIH-10842834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions that involve complex molecular interactions, such as cancer or neurodegenerative diseases.
✕Less likely to help
Patients with conditions that do not involve molecular or cellular mechanisms may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the methods used in cryo-electron microscopy (cryo-EM) to better visualize and understand the 3D structures of biological molecules and complexes. By integrating advanced computational modeling and deep learning algorithms, the project aims to improve the accuracy and reliability of atomic structure predictions that can be fitted to cryo-EM maps. Patients may benefit from this research as it could lead to better drug design and targeting strategies for various diseases by providing clearer insights into the molecular mechanisms involved. The research will also explore the validation of these computational strategies to ensure they are robust and reproducible.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in drug design and treatment strategies for various diseases by providing clearer insights into molecular structures.
How similar studies have gone: Other research in the field of cryo-electron microscopy has shown promising results, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Old Dominion University
Norfolk, United States Active
Researchers
- Principal investigator: Wriggers, Willy R — Old Dominion University
- Study coordinator: Wriggers, Willy R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.