Impaired B Cell and Vaccine Responses in Kidney Disease
Official title: Impaired B Cell and Vaccine Responses with Advance Renal Disease
Funded at VA Eastern Colorado Health Care System · NIH-11594968 · Data updated 2026-11-12
This project looks at why vaccines may not work as well for people with advanced kidney disease and how their immune system makes antibodies after vaccination.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2027 |
| NIH project number | 5I01CX002137-05 |
| Project ID | NIH-11594968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease or end-stage renal disease who receive vaccines and are undergoing care at participating sites.
✕Less likely to help
Patients without kidney disease or those not receiving pneumococcal vaccination at this time may not directly benefit.
What this research studies
If you have kidney disease, your body might not respond to vaccines as strongly as others. The study will examine B cells and germinal centers to understand how antibody production and maturation are affected by CKD and ESRD, especially after pneumococcal vaccination. Researchers will analyze mucosal and blood samples to see how antibodies are formed and how long they last. The goal is to uncover the biological reasons for weaker vaccine responses so future therapies can boost protection.
Why it matters
Potential benefit: Better understanding of why vaccines may be less effective in kidney disease patients could lead to improved vaccination strategies and healthier lives.
How similar studies have gone: Earlier work suggests reduced antibody responses in CKD/ESRD, but the exact mechanisms are not fully understood and this study aims to clarify them.
Where this research is happening
-
VA Eastern Colorado Health Care System
Aurora, United States Active
Researchers
- Principal investigator: Jani, Alkesh Harihar — VA Eastern Colorado Health Care System
- Study coordinator: Jani, Alkesh Harihar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.