Impact of secondhand smoke and e-cigarette vapor on lung and placenta health
Official title: Receptor for advanced glycation end-products signaling induction in the lung and placenta due to secondhand smoke and e-cigarette vapor
Funded at Brigham Young University · NIH-10437516 · Data updated 2026-11-12
This study looks at how secondhand smoke and e-cigarette vapor can affect the lungs and placenta during pregnancy, especially focusing on a specific receptor that can cause inflammation, to help understand the risks for moms and their babies and find ways to reduce those risks.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | July 13, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $454,500 |
| NIH project number | 1R15HD108743-01 |
| Project ID | NIH-10437516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include pregnant individuals who have been exposed to secondhand smoke or e-cigarette vapor.
✕Less likely to help
Patients who are not pregnant or who have not been exposed to secondhand smoke or e-cigarette vapor may not receive benefit from this research.
What this research studies
This research investigates how exposure to secondhand smoke and e-cigarette vapor affects the signaling pathways in the lung and placenta, particularly focusing on a receptor known as RAGE that is linked to inflammation. The study aims to understand the biological mechanisms behind placental complications that can arise from such exposures, which may lead to serious health issues for both mothers and their babies. By examining the effects of semi-synthetic glycosaminoglycan ethers (SAGEs) on RAGE interactions, the research seeks to identify potential therapeutic targets to mitigate these harmful effects. Patients may benefit from insights gained regarding the risks associated with secondhand smoke and e-cigarette use during pregnancy.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of placental complications and related health issues in mothers and infants.
How similar studies have gone: Previous research has shown that targeting RAGE can be effective in reducing inflammation related to various health conditions, suggesting potential success for this approach.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Arroyo, Juan a — Brigham Young University
- Study coordinator: Arroyo, Juan a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.