Impact of repeated head hits on brain health in young athletes

Subconcussive neurodegenerative progression in adolescent athletes

NIH-funded research Trustees of Indiana University · NIH-10991693

This study looks at how small hits to the head, which happen a lot in contact sports, might affect the brain health of young athletes, helping us understand the risks and create safety guidelines for them over the next four years.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionTrustees of Indiana University NIH-funded
Lab location1 site (Bloomington, United States)
Project IDNIH-10991693 on NIH RePORTER

What this research studies

This research investigates how repeated subconcussive head impacts, which are common in contact sports, affect the brain health of adolescent athletes. It focuses on understanding the long-term effects of these impacts on neural integrity and function during critical periods of brain development. By analyzing blood biomarkers and brain imaging, the study aims to identify potential risks and establish safety protocols for young athletes. The research will follow participants over a four-year period to assess changes in brain health related to their sports activities.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescent athletes aged 12 to 20 who participate in contact sports.

Not a fit: Patients who do not participate in contact sports or are outside the age range of 12 to 20 may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved safety protocols and interventions to protect young athletes from long-term brain damage.

How similar studies have performed: Previous research has indicated potential risks associated with subconcussive impacts, but this study aims to provide more definitive insights into their long-term effects, making it a novel approach.

Where this research is happening

Bloomington, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.