Impact of prenatal stress and pollution on gut health and autism
Gut-brain dysfunction following combined prenatal stressors: relevance for autism
This study looks at how stress during pregnancy and air pollution might affect the gut health and behavior of babies, especially in relation to autism, using mice to see how these factors change gut bacteria and behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11020963 on NIH RePORTER |
What this research studies
This research investigates how combined prenatal stress and exposure to air pollution affect gut health and behavior in offspring, particularly focusing on autism spectrum disorder (ASD). The study uses a mouse model to explore the effects of diesel exhaust particles and maternal stress during pregnancy on the gut microbiome and subsequent behavior. By examining changes in gut bacteria and behavioral outcomes, the research aims to understand the link between environmental factors and neurodevelopmental disorders. The findings could provide insights into how early life exposures influence health and development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include pregnant individuals exposed to environmental pollutants or experiencing significant stress.
Not a fit: Patients who are not pregnant or do not have a connection to autism spectrum disorder may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for autism spectrum disorder related to environmental factors.
How similar studies have performed: Other research has shown promising results in understanding the relationship between environmental exposures and neurodevelopmental disorders, suggesting that this approach is building on established findings.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Bilbo, Staci D — Duke University
- Study coordinator: Bilbo, Staci D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.