Impact of physical rehabilitation on frailty in heart failure patients
Official title: Effect of physical rehabilitation on molecular markers of frailty in heart failure
Funded at Boston University Medical Campus · NIH-10864183 · Data updated 2026-11-12
This study is looking at how physical rehabilitation can help older heart failure patients, especially those who may be feeling weak, by checking changes in their blood and seeing if it helps them feel better and do everyday activities more easily.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $501,631 |
| NIH project number | 1R21AG086679-01 |
| Project ID | NIH-10864183 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with heart failure, particularly those exhibiting signs of frailty.
✕Less likely to help
Patients who are younger than 21 or do not have heart failure may not benefit from this research.
What this research studies
This research investigates how physical rehabilitation can improve health outcomes for patients with heart failure, particularly those who are older and may also be experiencing frailty. The study will assess various biological markers to understand the relationship between rehabilitation and frailty in heart failure patients. By analyzing over 1000 proteins in the blood, researchers aim to identify specific changes that occur with rehabilitation, which could lead to better treatment strategies. Patients will be monitored for improvements in their ability to perform daily activities and overall quality of life.
Why it matters
Potential benefit: If successful, this research could lead to more effective rehabilitation strategies that significantly improve the quality of life for heart failure patients.
How similar studies have gone: Previous studies have shown promising results in improving outcomes for heart failure patients through rehabilitation, indicating that this approach has potential for success.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Nayor, Matthew G. — Boston University Medical Campus
- Study coordinator: Nayor, Matthew G.
Related research
Other NIH-funded projects on the same topics.
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Developing predictive models for frailty in heart failure patients using electronic health records.
This study is looking at how frailty affects older adults with heart failure by using health records to find patterns and risks, with the goal of helping doctors make better decisions for patient care.
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Understanding how physical frailty affects symptom management in heart failure patients
This study is looking at how being physically frail affects adults with heart failure in recognizing and managing their symptoms, like shortness of breath, to help improve their health and find better ways to support them.
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Investigating frailty and aging in childhood cancer survivors
This study is looking at childhood cancer survivors to see how they might face health challenges similar to older adults as they grow up, and it aims to find ways to help them stay strong and healthy by exploring treatments that could improve their well-being.
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AI-supported heart failure diagnosis and management in Rwanda
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HF endotypes in heart failure using ethical multi-modal AI and molecular data
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.