Impact of new onset type 1 diabetes on young children's brain health
Official title: Cognitive, structural and functional impact of new onset type 1 diabetes on the brain of young children: Understanding risks and protective factors
Funded at Nemours Children's Clinic · NIH-10974088 · Data updated 2026-11-12
This study is looking at how starting type 1 diabetes might change the way children's brains develop from ages 4 to 10, and it’s for kids with diabetes and their families to help understand how managing blood sugar can affect thinking and feelings over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nemours Children's Clinic NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $277,540 |
| NIH project number | 1U01DK140734-01 |
| Project ID | NIH-10974088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 4 to 10 years who have recently been diagnosed with type 1 diabetes.
✕Less likely to help
Patients who are older than 10 years or those with diabetes for an extended period may not benefit from this research.
What this research studies
This research investigates how new onset type 1 diabetes affects the brain development of children aged 4 to 10 years. By using advanced brain imaging techniques and neurocognitive assessments, the study aims to identify changes in brain structure and function in children with diabetes compared to their healthy peers. The research will also explore the effects of blood glucose management on cognitive and psychosocial outcomes over time. This longitudinal study will include a diverse group of children to understand the broader implications of diabetes on brain health.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management strategies for cognitive and emotional challenges faced by children with type 1 diabetes.
How similar studies have gone: Previous research has shown significant impacts of diabetes on brain health in children, suggesting that this study's approach is built on established findings.
Where this research is happening
-
Nemours Children's Clinic
Jacksonville, United States Active
Researchers
- Principal investigator: Mauras, Nelly — Nemours Children's Clinic
- Study coordinator: Mauras, Nelly
Related research
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A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.