Impact of maternal obesity and inflammation on the brain development of children
Effects of maternal obesity and inflammation on offspring brain development
This study is looking at how being overweight during pregnancy might affect how babies' brains develop, and it's for pregnant women of all sizes who want to understand how their health could impact their child's future thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-10660984 on NIH RePORTER |
What this research studies
This research investigates how maternal obesity during pregnancy affects the brain development of infants. It aims to understand the specific brain structures and functions that are impacted by the inflammatory environment associated with obesity. By recruiting both normal-weight and obese pregnant women, the study will analyze inflammatory markers and correlate them with brain development outcomes assessed through advanced MRI and neurodevelopmental tests. The goal is to uncover the mechanisms behind these changes and their long-term effects on cognitive functioning in children.
Who could benefit from this research
Good fit: Ideal candidates for participation include pregnant women who are either of normal weight or classified as obese.
Not a fit: Patients who are not pregnant or those who do not fall into the categories of normal-weight or obese may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions for cognitive development issues in children born to obese mothers.
How similar studies have performed: Previous research has shown associations between maternal obesity and cognitive outcomes in children, suggesting that this study builds on established findings rather than exploring a completely novel area.
Where this research is happening
Little Rock, United States
- Arkansas Children's Hospital Res Inst — Little Rock, United States (Active)
Researchers
- Principal investigator: Ou, Xiawei — Arkansas Children's Hospital Res Inst
- Study coordinator: Ou, Xiawei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.