Impact of hormone therapy on heart health in transmasculine young adults
Official title: Cardiometabolic Impact of Gender-Affirming Hormone Therapy in Transmasculine Young Adults
Funded at Medical College of Wisconsin · NIH-11036897 · Data updated 2026-11-12
This study is looking at how hormone therapy for transmasculine young adults affects heart health, especially in relation to stress and hormone changes, to help improve healthcare for transgender individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | February 1, 2025 |
| Project end | March 21, 2025 |
| Funding year | 2025 |
| Award (this year) | $779,771 |
| NIH project number | 1R01HL177518-01 |
| Project ID | NIH-11036897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are transmasculine young adults aged 21 and under who are receiving or considering gender-affirming hormone therapy.
✕Less likely to help
Patients who are not undergoing hormone therapy or are outside the age range of 21 and under may not benefit from this research.
What this research studies
This research investigates how gender-affirming hormone therapy (GAHT) affects cardiovascular health in transmasculine young adults. It aims to understand the cardiometabolic risks associated with GAHT, particularly focusing on how chronic stress and hormonal changes influence vascular physiology. By examining the effects of testosterone and estradiol levels on cardiovascular health, the study seeks to provide higher-quality data that can inform healthcare practices and policies for transgender individuals. Participants may undergo assessments of their cardiovascular health and hormone levels throughout the study.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular health outcomes and tailored healthcare strategies for transmasculine individuals undergoing hormone therapy.
How similar studies have gone: While there is limited high-quality research on this specific topic, previous studies have indicated significant cardiovascular health disparities in transgender populations, suggesting a need for further investigation.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Widlansky, Michael E — Medical College of Wisconsin
- Study coordinator: Widlansky, Michael E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.