Impact of heavy metals on intestinal health
Official title: Heavy metals exposure regulates secretory lineage in intestinal injury
Funded at University of New Mexico Health Scis Ctr · NIH-10804040 · Data updated 2026-11-12
This study looks at how being around heavy metals from old uranium mines might impact gut health, especially for people living nearby, by exploring how these toxins can lead to inflammation and a higher chance of developing colorectal cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | September 19, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $379,123 |
| NIH project number | 1R01ES034400-01A1 |
| Project ID | NIH-10804040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living near abandoned uranium mine sites who may be experiencing intestinal health issues.
✕Less likely to help
Patients who do not live in areas affected by heavy metal contamination are unlikely to benefit from this research.
What this research studies
This research investigates how exposure to heavy metals, particularly from abandoned uranium mine sites, affects the health of the intestines. It focuses on understanding the molecular changes in intestinal cells that occur due to chronic exposure to these environmental toxins. By analyzing the effects of uranium-bearing dust on intestinal epithelial cells, the study aims to uncover the mechanisms behind intestinal inflammation and increased risk of colorectal cancer. Patients living near contaminated sites may experience these health issues, and the research seeks to provide insights into potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for intestinal diseases linked to heavy metal exposure.
How similar studies have gone: Previous research has shown that environmental toxins can significantly impact intestinal health, suggesting that this study's approach could yield valuable insights.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: In, Julie Goeun — University of New Mexico Health Scis Ctr
- Study coordinator: In, Julie Goeun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.