Impact of gut and body inflammation on antibiotic-resistant gut bugs in kids
Official title: Impact of gastrointestinal and systemic inflammation on colonization with extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) in children
Funded at Washington State University · NIH-11453580 · Data updated 2026-11-12
A study to understand how inflammation in the body and gut affects colonization by antibiotic-resistant bacteria in children.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project start | August 24, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $323,446 |
| NIH project number | 1R21AI197019-01A1 |
| Project ID | NIH-11453580 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are infants and toddlers in the Guatemala cohort who have stool and serum samples and are within the 6–24 month age range.
✕Less likely to help
Children outside the study’s age window or without available samples may not benefit from these findings.
What this research studies
This project will follow a group of young children over time to see how markers of inflammation and gut health relate to colonization by resistant bacteria in the intestine. Researchers will analyze stool and blood samples collected at 6, 15, and 24 months to study inflammation, gut barrier function, and the microbiome using advanced analyses like metagenomics and targeted metabolomics. By combining host and microbial data, the study aims to map out how inflammation and microbiome changes may drive colonization and its persistence. The findings could reveal targets to prevent colonization and related infections.
Why it matters
Potential benefit: If successful, this work could lead to strategies to prevent colonization with resistant bacteria and reduce infection risk in young children.
How similar studies have gone: Similar approaches have shown that inflammation and microbiome shifts relate to colonization but this study adds longitudinal, mechanistic links.
Where this research is happening
-
Washington State University
Pullman, United States Active
Researchers
- Principal investigator: Ramay, Brooke M — Washington State University
- Study coordinator: Ramay, Brooke M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.