Impact of embryo manipulation on metabolism in IVF children
Official title: Altered metabolism in embryo generated by in vitro fertilization
Funded at University of California, San Francisco · NIH-11059250 · Data updated 2026-11-12
This study is looking at how changing embryos before they are implanted during IVF might affect the health and growth of children born from these procedures, helping to ensure better outcomes for families using assisted reproductive technologies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $663,719 |
| NIH project number | 5R01HD108166-03 |
| Project ID | NIH-11059250 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include families undergoing in vitro fertilization and those with children conceived through assisted reproductive technologies.
✕Less likely to help
Patients who conceived naturally without the use of assisted reproductive technologies may not benefit from this research.
What this research studies
This research investigates how manipulating embryos before implantation during in vitro fertilization (IVF) affects their metabolism and the health of children born from these procedures. The study aims to understand whether these manipulations lead to long-term health issues, such as altered growth and glucose metabolism, in offspring. By examining the molecular mechanisms involved, the research seeks to provide insights into the potential risks associated with assisted reproductive technologies. This could help inform better practices in IVF and improve outcomes for families undergoing these treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for children conceived through IVF by identifying and mitigating potential metabolic risks.
How similar studies have gone: Previous research has indicated potential risks associated with embryo manipulation in IVF, but this study aims to explore these effects in greater depth, making it a novel investigation.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Rinaudo, Paolo — University of California, San Francisco
- Study coordinator: Rinaudo, Paolo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.