Impact of early triclosan exposure through breastfeeding on liver health in adults
Effects of early life Triclosan exposure through lactation on the gut-liver axis and its implications in the development of steatotic liver disease in adults
This study looks at how being exposed to triclosan, a common ingredient in many products, through breastfeeding might affect liver health later in life, especially for those who eat a high-fat diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11133614 on NIH RePORTER |
What this research studies
This research investigates how exposure to triclosan, a common antiseptic found in many consumer products, during early life through breastfeeding may influence the development of liver diseases in adulthood. The study examines the interaction between triclosan and high-fat diets, focusing on how this exposure could lead to metabolic dysfunction and liver damage. By using animal models, the research aims to uncover the mechanisms by which early-life exposure to this chemical affects liver health later in life, potentially leading to conditions like steatotic liver disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who were exposed to triclosan through breastfeeding and are now experiencing liver health issues.
Not a fit: Patients who have not been exposed to triclosan during early life or those without liver health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for liver diseases linked to early-life environmental exposures.
How similar studies have performed: Previous research has indicated that environmental toxicants can influence metabolic diseases, suggesting that this approach may yield significant insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Tukey, Robert H — University of California, San Diego
- Study coordinator: Tukey, Robert H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.