Impact of early triclosan exposure through breastfeeding on liver health in adults
Official title: Effects of early life Triclosan exposure through lactation on the gut-liver axis and its implications in the development of steatotic liver disease in adults
Funded at University of California, San Diego · NIH-11133614 · Data updated 2026-11-12
This study looks at how being exposed to triclosan, a common ingredient in many products, through breastfeeding might affect liver health later in life, especially for those who eat a high-fat diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 6, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $794,841 |
| NIH project number | 1R01ES036571-01A1 |
| Project ID | NIH-11133614 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who were exposed to triclosan through breastfeeding and are now experiencing liver health issues.
✕Less likely to help
Patients who have not been exposed to triclosan during early life or those without liver health concerns may not benefit from this research.
What this research studies
This research investigates how exposure to triclosan, a common antiseptic found in many consumer products, during early life through breastfeeding may influence the development of liver diseases in adulthood. The study examines the interaction between triclosan and high-fat diets, focusing on how this exposure could lead to metabolic dysfunction and liver damage. By using animal models, the research aims to uncover the mechanisms by which early-life exposure to this chemical affects liver health later in life, potentially leading to conditions like steatotic liver disease.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for liver diseases linked to early-life environmental exposures.
How similar studies have gone: Previous research has indicated that environmental toxicants can influence metabolic diseases, suggesting that this approach may yield significant insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Tukey, Robert H — University of California, San Diego
- Study coordinator: Tukey, Robert H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.