Impact of early exposure to metal mixtures on children's lung health
Effect of Early-Life Exposure to Metal Mixtures on Lung Function and Mitochondrial DNA in Children
This study is looking at how being exposed to harmful metals during pregnancy and early childhood can affect kids' lung health, using baby teeth to see how much metal they were exposed to over time, so we can better understand when children are most at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10609404 on NIH RePORTER |
What this research studies
This research investigates how exposure to harmful metals during pregnancy and early childhood affects lung function in children. By measuring metal levels in deciduous teeth, which capture exposure over time, the study aims to identify critical periods when children are most vulnerable to these toxins. The researchers will analyze the cumulative effects of 14 different metals, providing insights into how these exposures may influence lung development and function. This innovative approach allows for a noninvasive way to track metal exposure from gestation through early childhood.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women and children up to 6 years old who may have been exposed to metal mixtures.
Not a fit: Patients who are not pregnant or do not have children under the age of 6 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for lung health issues in children exposed to toxic metals.
How similar studies have performed: While studies have examined individual metal exposures, this research is novel in its approach to assess the combined effects of multiple metals simultaneously.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Parvez, Muhammad F — Columbia University Health Sciences
- Study coordinator: Parvez, Muhammad F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.